PROSPEK HIDRAZON HASIL SINTESIS SEBAGAI ANTIKANKER PAYUDARA

Abstract

The hydrazone is a substitution compound with a stable imine type that has an azomethine group (-NH-N=C-R-) which plays a role in its biological activity, one of which is as a breast anticancer. As of this writing, it is reported synthesize the hydrazone compound with IUPAC name (Z)-4-((2-isonicotinyl hydrazone)methyl)-2- methoxyphenyl benzensulfonate. The hydrazone was synthesized by reacting the Oalklated compound 4- formyl-2-methoxyphenyl benzenesulfonate and isoniazid with glacial acetic acid catalyst and ethanol absolut as solvent. The structure of the synthesized compounds was confirmed through UV, FTIR and LC-MS spectroscopic analysis. The method used in the synthesis of hydrazone compounds was microwave irradiation. The yield obtained from the synthesis of hydrazone compounds was 88.45%.