AKTIVITAS ANTIMIKROBA EKSTRAK KO-KULTUR ISOLAT JAMUR LOKAL RIAU Penicillium sp. LBKURCC34 DAN Penicillium sp. LBKURCC30

Abstract

Penicillium sp. LBKURCC34 and LBKURCC30 are fungi that have the potential to produce secondary metabolites that have many activities. This study was conducted to produce secondary metabolites using co-culture fermentation. Extraction of secondary metabolites was carried out using ethyl acetate (EtOAc), butanol (BuOH) and acetone (Ace). Antimicrobial activity test of these three extracts was conducted using disc diffusion method. Based on the clear zone area at concentrations of 2000 and 200 μg/disk, the three extracts did not have antibacterial activity against the four pathogenic microbes. Antifungal test results at a concentration of 2000 μg/disk these three extracts have antifungal activity against C. albicans fungi, while at a concentration of 200 μg/disk only EtOAc and BuOH extracts have antifungal activity.