dc.contributor.author |
Hidayat, Rohim |
|
dc.date.accessioned |
2023-03-14T03:16:35Z |
|
dc.date.available |
2023-03-14T03:16:35Z |
|
dc.date.issued |
2022-12 |
|
dc.identifier.citation |
Perpustakaan |
en_US |
dc.identifier.other |
Elfitra |
|
dc.identifier.uri |
https://repository.unri.ac.id/handle/123456789/10900 |
|
dc.description.abstract |
Pyrazoline is a five-ring heterocyclic compound containing two nitrogen atoms in the
ring. Pyrazoline had a wide variety of biological activities, such as an inhibitor of the
tyrosinase enzyme. Pyrazoline 4-(3-(4-florophenyl)-5-(2-methoxyphenyl)-4-5-dihydro-
1H-pyrazole-1-yl)benzenesulfonamide has been successfully synthesized through
various stages. The first step is the formation of chalcone compounds by reacting 4-
floroacetophenone and 2-methoxybenzaldehyde through the Claisen-Schmidt reaction
using microwave irradiation. Then it is reacted with
4-hydrazinylbenzenesulfonamide which is synthesized through azotation and further
reduction reactions, then the cyclization reaction between chalcone and
4-hydrazinylbenzensulfonamide by reflux method for 9 hours at 80°C. The structure of
the synthesized compounds was confirmed by characterization using ultraviolet (UV)
spectroscopy, fourier transform infra red (FTIR) and high-resolution mass spectroscopy
(HRMS). The yield obtained from this pyrazoline synthesis was 93%. The toxicity of
pyrazoline compounds was tested using the Brine Shrimp Lethality Test (BSLT)
method using Artemia salina leach. The pyrazoline compound obtained was non-toxic
with an LC50 value of 3,706 μg/mL. |
en_US |
dc.description.provenance |
Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2023-03-14T03:16:35Z
No. of bitstreams: 1
Rohim Hidayat _compressed.pdf: 178341 bytes, checksum: 80e959d7abb3bb0385c95e158428c24e (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2023-03-14T03:16:35Z (GMT). No. of bitstreams: 1
Rohim Hidayat _compressed.pdf: 178341 bytes, checksum: 80e959d7abb3bb0385c95e158428c24e (MD5)
Previous issue date: 2022-12 |
en |
dc.description.sponsorship |
Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riau |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elfitra |
en_US |
dc.subject |
Brine Shrimp Lethality Test |
en_US |
dc.subject |
pyrazoline |
en_US |
dc.subject |
toxicity test |
en_US |
dc.title |
SINTESIS DAN UJI TOKSISITAS PIRAZOLIN 4-(3-(4-FLOROFENIL)-5- (2-METOKSIFENIL)-4-5-DIHIDRO-1H-PIRAZOL-1- IL)BENZENASULFONAMIDA SEBAGAI INHIBITOR ENZIM TIROSINASE |
en_US |
dc.type |
Article |
en_US |
dc.contributor.supervisor |
Eryanty, Yum |
|