SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN ASIMETRIS 1-BENZIL-3-((E)-2- KLOROBENZILIDEN)-5-((E)- 4-METOKSIBENZILIDEN) PIPERIDIN-4-ON

Abstract

Curcumin is one of the secondary metabolites that chemically belongs to the phenolic group. Curcumin has long been known as a yellow substance in the rhizomes of thefamily of plants Zingiberaceae, which are used as traditional medicine in Asia. Curcumin analogues may have the same or even better pharmacological properties. The asymmetric curcumin analogue compound 1- benzyl-3-((e)-2-chlorobenzyliden)-5-((e)-4-methoxybenzyliden) piperidine-4-one was synthesized by themethod One-Pot through the Claisen Schmidt reaction using an alkaline catalyst. . The purity of the asymmetric curcumin analog compound was determined by TLC test, melting point measurement and HPLC analysis. The structure of the synthesized compound was obtained from UV, FTIR, 1H-NMR, and HRMS spectroscopic studies. In the synthesis of asymmetric curcumin analogue compounds, the yield was 3.47% and the toxicity test of this compound used the Brine Shrimp Lethality Test (BSLT) method. The LC50 value obtained was 173.78 g/ml, based on these results it can be concluded that the asymmetric curcumin analog compound 1-benzyl-3-((e)-2- chlorobenzyliden)-5-((e)-4-methoxybenzyliden) piperidine-4-one is toxic.