Abstract:
Curcumin is one of the secondary metabolites that chemically belongs to the
phenolic group. Curcumin has long been known as a yellow substance in the
rhizomes of thefamily of plants Zingiberaceae, which are used as traditional
medicine in Asia. Curcumin analogues may have the same or even better
pharmacological properties. The asymmetric curcumin analogue compound 1-
benzyl-3-((e)-2-chlorobenzyliden)-5-((e)-4-methoxybenzyliden) piperidine-4-one
was synthesized by themethod One-Pot through the Claisen Schmidt reaction
using an alkaline catalyst. . The purity of the asymmetric curcumin analog
compound was determined by TLC test, melting point measurement and HPLC
analysis. The structure of the synthesized compound was obtained from UV,
FTIR, 1H-NMR, and HRMS spectroscopic studies. In the synthesis of
asymmetric curcumin analogue compounds, the yield was 3.47% and the toxicity
test of this compound used the Brine Shrimp Lethality Test (BSLT) method. The
LC50 value obtained was 173.78 g/ml, based on these results it can be concluded
that the asymmetric curcumin analog compound 1-benzyl-3-((e)-2-
chlorobenzyliden)-5-((e)-4-methoxybenzyliden) piperidine-4-one is toxic.