Browsing by Author "Hakim, Luqman"

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    Diabetes Melitus
    (2013-04-18) Winarto; Hakim, Luqman
    Diabetes mellitus is one of a metabolism disorder with characteristic of the hyperglycemia caused by abnormal insulin secretion resistance, insulin metabolism, or both. Diabetes mellitus with hyperglycemia cause increasing oxidative stress and distrubance antioxidant defence. Pandanus conoideus Lam. oil containing ^-carotene, p-cryptoxanthin and a-tocopherol can reduce oxidative stress. This study aimed to determine the effect of glibenclamide combination P. conoideus Lam. oil on uric acid serum. Wistar rats were divided into four groups; normal group, DM group, diabetic group given glibenclamide and diabetic groups were given glihenclamide combination Pandanus conoideus Lam. oil The results showed significant differences (p <0.05) on uric acid serum. Based on this study; it can be concluded that administration of glibenclamide combination Pandanus conoideus Lam. oil can decrease uric acid average in diabetic rats.
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    PERBAIKAN PARENKHIM GINJAL DAN HEPAR DENGAN PEMBERIAN MINYAK BUAH MERAH (Pandanus conoideus L.) PADA TIKUS PUTIH (Rattuss norwegicus) GALUR WISTAR DIABETIK
    (2014-06-02) Winarto; Hakim, Luqman; Maryanti, Esy
    Jumlah penderita diabetes mellitus (DM) tiap tahunnya bertambah banyak jumlahnya di Indonesia. Angka prevalensi DM tingkat nasional sebesar 5,6 %. Provinsi Riau menduduki nomor tiga terbesar angka prevalensi DM di antara provinsi-provinsi di Indonesia. Angka prevalensi DM di provinsi Riau sebesar 11,2 % (Sugondo, 2011) Hiperglikemia pada DM menyebabkan stres oksidatif (Sreemantula et al., 2005) pada sistem seluler karena produksi oksidan (radikal bebas) melebihi kemampuan antioksidan (Vincent et al., 2004). Hiperglikemia menginduksi pembentukan reactive oxygen species (ROS) meliputi superoksida, hidrogen peroksida, nitrik oksida, dan radikal hidroksil (Robertson et al., 2003) dan mengaktivasi stres oksidatif melalui mekanisme glikasi non enzimatik protein, auto-oxidative glycation, aktivasi protein kinase C (PKC), dan peningkatan jalur poliol (Chiarelli et al., 2004).