Browsing by Author "Eryanti, Y."

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    SINTESIS SENYAWA KALKON TURUNAN 3’,4’-DIMETOKSI ASETOFENON DAN UJI TOKSISITAS MENGGUNAKAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)
    (2013-07-19) Hastiningrum, W. P.; Eryanti, Y.; Zamri, A.
    Three new chalcones of 3’,4’-dimethoxy acetophenone derivative were synthesized by stirrer method with alkaline sodium hydroxide catalyst at room temperature. They were (E) -1,3-bis (3,4 dimetoksifenil) prop-2-en-1-one (CA1), (E) -3 - (2,3 -dimetoksifenil) -1 - (3,4-dimetoksifenil) prop-2-en-1-one (CA2) and (E) -3 - (2,4,5-trimetoksifenil) -1 - (3,4-dimetoksifenil ) prop-2-en-1-one (CA3). Chalcone yield compounds obtained were 98%, 84.24% and 79.13%, respectively. The compounds were identified using UV spectroscopy, IR, 1H NMR and MS. Toxicity of chalcones tested using Brine Shrimp Lethality Test (BSLT) against larvae of Artemia salina Leach. CA1, CA2 and CA3 compounds had LC50 i.e., 17.022 mg / mL, 4.645 mg / mL and 648.634 mg / mL, respectively . The result showed that CA1 and CA2 were toxic as their LC50 values less than 200 mg / mL, while CA3 was found to be non- toxic compound.
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    SINTESIS SENYAWA KURKUMIN TURUNAN 1-BENZIL-4-PIPERIDINON DAN UJI TOKSISITAS DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)
    (2013-07-19) Wahyuni, E.; Eryanti, Y.; Zamri, A.
    Curcumin is one of secondary metabolites classified into the class of fenolic that are known to have biological activities such as anti-oxidant, anti-diabetic, anti-inflammatory and anti-cancer. Therefore, many curcumins become model of target compounds with variation structure. Curcumins of 1-benzyl-piperidin-4-on derivative were synthesized using the microwave irradiation with a base catalyst (NaOH) and an acid catalyst metanasulfonat. The rendement result of curcumins analog were as followed: (3E,5E)-3,5-bis(2’-klorobenzilidin)-1-benzil-4-piperidinone (1) about 93,03%, (3E,5E)-3,5-bis(4’-klorobenzilidin)-1-benzil-4-piperidinone (2) about 14,40% and (3E,5E)-3,5-bis(3’-bromobenzilidin)-1-benzil-4-piperidinone (3) about 33%. The purity of all compounds has been tested using TLC, melting point test and analytical HPLC. Then, they were identified using UV, IR, 1NMR and MS spectroscopy. The toxicity test of curcumins was done by Brine Shrimp Lethality Test (BSLT) method which was indicated by LC50 <200 μg/mL. Between the three analog curcumins only (1) has potensial as anti-cancer by LC50= 22,44 μg/mL.
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    SINTESISDAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 4-PIPERIDINON
    (2014-03-27) Nurwantari, W.; Eryanti, Y.; Jasril; Zamri, A.
    Curcumin is one of secondary metabolites included into the fenolic group which was known to have various of biological activities such as antimicroba, anticancer, antioxidance, antitumor and anti-inflammatory. Therefore, curcumin through the variation of thestructurecould became amodel for target molecule. In this research, curcumin analog coumpond of 4-piperidone derivative was synthesized using microwave irradiation withan acid catalyst (SOCl2). The rendement resultedfrom curcumin analog is(3E,5E)-3,5-bis (2-chlorobenzilidyn)-piperidyn-4-one(1) 94,35%. The purity ofompoundhas been tested using TLC, melting pointtest, and analytical HPLC.The compoundresulted was characterized usingUV, IR, 1 H NMR and 13 C NMR.The toxicity test done by Brine ShrimpLethality Test(BSLT) method toArtemia salinaLeach larvagaveLC50 value< 200 μg/mL.The resultshowedthatcompound(1) haspotential asananticancerwithLC50 value= 55,46µg/mL.