Browsing by Author "Eryanti, Y."
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Item SINTESIS ANALOG KURKUMIN TURUNAN 1-BENZIL 4-PIPERIDINON MENGGUNAKAN KATALIS BASA DAN UJI AKTIVITAS SEBAGAI ANTIBAKTERI(2014-03-27) Wahyuni, S.; Eryanti, Y.; Zamri, A.; JasrilCurcumin is one of secondary metabolites with phenolic group which was known to have various biological activities such as antimicroba, anticancer, antioxidant, antitumor and anti-inflammatory activities. In this research, curcumin analog of 1-benzil-4- piperidone derivative was synthesized using microwave irradiation with catalyst NaOH. The rendement (YN2) resulted 99.39%. All compounds were characterized using UV spectrophotometer, IR spectrophotometer, 1 H NMR, and 13 C NMR spectrometers. The antibacterial activity was evaluated using the agar diffusion method. Antibacterial activity test was carried out at concentrations of 20, 30, 40, 50 , and 60 mg/disc against Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram negative bacteria (Escherichia coli and Salmonella enteritidis). YN 2 compounds obtained showed different antibacterial activity against different bacteria.Item SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KURKUMIN (3E,5E)-3,5-BIS(2’-HIDROKSIBENZILIDIN)-1-METILPIPERIDIN-4 -ON(2014-03-27) Hasanah, U.; Zamri, A.; Balatif, N.; Eryanti, Y.The derivatives of curcumin are second ary metabolites belonging to the phenolic group. Some of them were reported to have biological activities such as anti -i nfl ammatory, anticancer and antioxidant activities. In this study, acurcumin of (3E,5E)-3,5bis(2’-hidroxybenzilidin)-1-metilpiperidin-4-one from 1-methyl-4-pi peridinone with 2-hydroxy benzaldehideh as been successfully synthesized using microwave irradiation method with NaOH (20 %) as catalyst . React ion was carried out for 1 minute at 180 watt . The compound resulted was in the form of yellow crystal withayield of 72 %. The compound was characterized by measuring its melting point, identifying by TLC, and elucidated by UV-Vis, FT- IR, MS, 1 H NMR, and 13 C NMR. Our result show edthatthecom pound had the target edmolecule structure. Ant i bacterial test was carried out using the agar di ffusion method against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Salmonella enteritidis. Overall, inhibition zone ran ged from 6.5 t o 10 mm and showed avery weak activity.Item SINTESIS DAN UJI TOKSISITAS BEBERAPA SENYAWA ANALOG PARA METOKSI KALKON(2013-03-07) Perdana, F.; Eryanti, Y.; Zamri, A.Chalcone is a very interesting compound because it is known to have various of biological activities such as antimicroba, antifungi, anesthetics, anticancer, antimalaria, antioxidance, antitumor and anti-inflammatory. Moreover, natural and synthetic compounds of chalcone have roles as precursors for other compounds. Therefore, many chalcones become model structures of target compounds by researcher. In this research, chalcone methoxy analogue compounds have been synthesized using stirer method and using base catalyst NaOH. The synthesized results obtained are (E)-3-(4- isopropylphenyl)-1-(4'-methoxyphenyl)prop-2-en-1-one (1), (E)-1-(4'-methoxyphenyl)- 3-p-tolylprop-2-en-1-one (2) and (E)-3-(3-bromophenyl)-1-(4'-methoxyphenyl)prop-2- en-1-one (3). The purity of all compounds have been tested using TLC, melting point test, analytical HPLC. Then they are characterized using UV, FTIR, 1H-NMR and MS spectroscopy. The toxicity test of the novel compounds was done by Brine Shrimp Lethality Test (BSLT) method. The all compounds showed very good activity with LC50 value < 200 μg/mLItem SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 1-METIL-4-PIPERIDINON(2013-07-19) Hidayah, N.; Eryanti, Y.; Zamri, A.Curcumin is one of secondary metabolites included into the class of group fenolic which was known to have biological activity such as anticancer, antioxidant, antidiabetic, and anti-inflammatory. Therefore , curcumin becomes model of target compounds that have various structure. In this research, curcumin analog coumponds of 1- methyl-4- piperidone derivative were synthesized using microwave irradiation with a base catalyst (NaOH). The rendement obtained from each of curcumin analogs are (3E,5E)-3,5-bis (2-chlorobenzilidyn)-1-methylpiperidyn-4-one (1) with value 38,86 %, (3E,5E)-3,5-bis (4-chlorobenzilidyn)-1-methylpiperidyn-4-one (2) with value 65,60 % dan (3E,5E)-3,5-bis (3-bromobenzilidyn)-1-methylpiperidyn-4-one (3) with value 19,73%. The purity of all compounds has been tested using TLC, melting point test, and analytical HPLC. The identification of curcumin analog coumponds was analysed using UV, IR, 1H NMR and MS. The toxicity test done by Brine Shrimpt Lethality Test (BSLT) method to artemia salina Leach larva showed that LC50 < 200 μg/mL. The result toxicity test to all of compounds showed that the coumpond(1) is the most toxic compared to (2) and (3).Item SINTESIS DUA ANALOG 4’-BROMO CALKON MELALUI KONDENSASI ALDOL DAN UJI ANTIOKSIDAN METODE FERI TIOSIANAT(2013-03-07) Maharani; Yuharmen; Eryanti, Y.Chalcons are precursors of open chain flavonoids and isoflavonoids present in edible plants. Their derivatives have become attention for researchers because of their potentioal pharmacological effects. In finding of new efficient antioxidant compounds, substituted-chalcones have been synthesized by condensing benzaldehyde derivatives with 4’-bromoacetophenone in conventional method at room temperature based on Claisen-Schmidt condensation on alkali condition. The structures of the compounds were characterized by using infra red and nuclear magnetic resonance spectroscopy. In terms of antioxidant activity by using ferric thiocyanate (FTC) method, the compounds showed moderate antioxidant activityItem SINTESIS SENYAWA KALKON TURUNAN 3’,4’-DIMETOKSI ASETOFENON DAN UJI TOKSISITAS MENGGUNAKAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)(2013-07-19) Hastiningrum, W. P.; Eryanti, Y.; Zamri, A.Three new chalcones of 3’,4’-dimethoxy acetophenone derivative were synthesized by stirrer method with alkaline sodium hydroxide catalyst at room temperature. They were (E) -1,3-bis (3,4 dimetoksifenil) prop-2-en-1-one (CA1), (E) -3 - (2,3 -dimetoksifenil) -1 - (3,4-dimetoksifenil) prop-2-en-1-one (CA2) and (E) -3 - (2,4,5-trimetoksifenil) -1 - (3,4-dimetoksifenil ) prop-2-en-1-one (CA3). Chalcone yield compounds obtained were 98%, 84.24% and 79.13%, respectively. The compounds were identified using UV spectroscopy, IR, 1H NMR and MS. Toxicity of chalcones tested using Brine Shrimp Lethality Test (BSLT) against larvae of Artemia salina Leach. CA1, CA2 and CA3 compounds had LC50 i.e., 17.022 mg / mL, 4.645 mg / mL and 648.634 mg / mL, respectively . The result showed that CA1 and CA2 were toxic as their LC50 values less than 200 mg / mL, while CA3 was found to be non- toxic compound.Item SINTESIS SENYAWA KURKUMIN TURUNAN 1-BENZIL-4-PIPERIDINON DAN UJI TOKSISITAS DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)(2013-07-19) Wahyuni, E.; Eryanti, Y.; Zamri, A.Curcumin is one of secondary metabolites classified into the class of fenolic that are known to have biological activities such as anti-oxidant, anti-diabetic, anti-inflammatory and anti-cancer. Therefore, many curcumins become model of target compounds with variation structure. Curcumins of 1-benzyl-piperidin-4-on derivative were synthesized using the microwave irradiation with a base catalyst (NaOH) and an acid catalyst metanasulfonat. The rendement result of curcumins analog were as followed: (3E,5E)-3,5-bis(2’-klorobenzilidin)-1-benzil-4-piperidinone (1) about 93,03%, (3E,5E)-3,5-bis(4’-klorobenzilidin)-1-benzil-4-piperidinone (2) about 14,40% and (3E,5E)-3,5-bis(3’-bromobenzilidin)-1-benzil-4-piperidinone (3) about 33%. The purity of all compounds has been tested using TLC, melting point test and analytical HPLC. Then, they were identified using UV, IR, 1NMR and MS spectroscopy. The toxicity test of curcumins was done by Brine Shrimp Lethality Test (BSLT) method which was indicated by LC50 <200 μg/mL. Between the three analog curcumins only (1) has potensial as anti-cancer by LC50= 22,44 μg/mL.Item SINTESISDAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 4-PIPERIDINON(2014-03-27) Nurwantari, W.; Eryanti, Y.; Jasril; Zamri, A.Curcumin is one of secondary metabolites included into the fenolic group which was known to have various of biological activities such as antimicroba, anticancer, antioxidance, antitumor and anti-inflammatory. Therefore, curcumin through the variation of thestructurecould became amodel for target molecule. In this research, curcumin analog coumpond of 4-piperidone derivative was synthesized using microwave irradiation withan acid catalyst (SOCl2). The rendement resultedfrom curcumin analog is(3E,5E)-3,5-bis (2-chlorobenzilidyn)-piperidyn-4-one(1) 94,35%. The purity ofompoundhas been tested using TLC, melting pointtest, and analytical HPLC.The compoundresulted was characterized usingUV, IR, 1 H NMR and 13 C NMR.The toxicity test done by Brine ShrimpLethality Test(BSLT) method toArtemia salinaLeach larvagaveLC50 value< 200 μg/mL.The resultshowedthatcompound(1) haspotential asananticancerwithLC50 value= 55,46µg/mL.