SINTESIS DAN UJI TOKSISITAS ANALOG KALKON TERSUBSTITUSI METOKSI

Abstract

Chalcones have some biological activities such as antimicrobe, antitumor, antioxidant, antiinflammatory, antimalaria, and anticancer. In this research, a methoxy substituted chalcone (E)-1-(phenyl)-3-(2-methoxyphenyl)-prop-2-en-1-one (EP1) was synthesized using kalium hydroxide as catalyst under microwave irradiation and the compound showed a good yield (49.18%) then characterized by UV, IR, 1H-NMR, and mass spectroscopy. The toxicity activity of this compound was determined using Brine Shrimp Lethality Test (BSLT) method against Artemia salina Leach larvae and showed a good activity with LC50 3.498 μg/mL. The result indicated that this compound was potential as anticancer.