PROSPEK SENYAWA HIDRAZON HASIL SINTESIS SEBAGAI ANTIKANKER PAYUDARA

Abstract

Hydrazone is a substituted compound with stable imine-type that has an azomethine groups (-NH-N=C-R-). The hydrazone (E)-N'-(3-methoxy-4-(propoxy)benziliden) isonicotinohydrazide (HDZ-ISZ) compound had been successfully synthesized in twostep of reaction process. The initial stage involved the formation of 3-methoxy-4- (propoxy)benzaldehyde (Vn-sb) through the O-alkylation reaction of propargylated substituted vanillin with a yield of 72%. The final stage entailed the formation of HDZ-ISZ compound through the condensation reaction between 3-methoxy-4- (propoxy)benzaldehyde and isoniazide using the stirring and heating methods. The yield obtained from the synthesized hydrazone was 64%. The putrity of subtituted vanilin and HDZ-ISZ compounds were tested by measuring the melting point, TLC and HPLC analysis. The structue of HDZ-ISZ compound was confirmed by characterization with UV, FTIR and LC-MS spectroscophy characterization.