Abstract:
Hydrazone is a substituted compound with stable imine-type that has an azomethine
groups (-NH-N=C-R-). The hydrazone (E)-N'-(3-methoxy-4-(propoxy)benziliden)
isonicotinohydrazide (HDZ-ISZ) compound had been successfully synthesized in twostep
of reaction process. The initial stage involved the formation of 3-methoxy-4-
(propoxy)benzaldehyde (Vn-sb) through the O-alkylation reaction of propargylated
substituted vanillin with a yield of 72%. The final stage entailed the formation of
HDZ-ISZ compound through the condensation reaction between 3-methoxy-4-
(propoxy)benzaldehyde and isoniazide using the stirring and heating methods. The yield
obtained from the synthesized hydrazone was 64%. The putrity of subtituted vanilin
and HDZ-ISZ compounds were tested by measuring the melting point, TLC and HPLC
analysis. The structue of HDZ-ISZ compound was confirmed by characterization with
UV, FTIR and LC-MS spectroscophy characterization.
