PERBANDINGAN METODE SINTESIS ONE-POT SENYAWA 3-(3-BROMOFENIL)-5-(2-METOKSIFENIL)-1-FENIL-4,5- DIHIDRO-PIRAZOL

Abstract

Pyrazoline is a five-ring heterocyclic compound with three carbon atoms and two adjacent nitrogen atoms. The presence of electron-rich nitrogen atoms causes these compounds have various biological activities, such as anticancer, antitumor and antioxidant. The pyrazoline (PF-3Br-2OMe) was synthesized by a one-pot three-component reaction between 2-methoxybenzaldehyde, 3-bromoacetophenone and phenylhydrazine with strong base catalyst (NaOH). The synthesis of pyrazoline compound PF-3Br-2OMe was done by comparison of microwave irradiation method, reflux and solvent free. The structure of synthesized compound were confirmed by UV, FTIR, NMR and HRMS spectra. It was concluded that the good method for synthesis of pyrazoline PF-3Br-2OMe in the case of yield was the reflux method, with a yield of 40.51%. While the method was superior in terms of reaction time was microwave irradiation method with reaction time of 1 minute and yield of 34.83%.