SINTESIS DAN UJI TOKSISITAS DUA SENYAWA ANALOG KURKUMIN SIMETRIS DARI SIKLOHEKSANON DENGAN TURUNAN METOKSIBENZALDEHID

Abstract

Curcumin is one of secondary metabolites included into the class of fenolic’s group, which was known to have biological activity such as anticancer, antioxidant, antidiabetic and anti-inflammatory. In this research, curcumin analog compounds of cyclohexanone and methoxybenzaldehide derivative were synthesized under microwave irradiation with NaOH. The yield obtained from curcumin analog of (2E,6E)-2,6-bis-(2-methoxybenzilidyn)-cyclohexanone (A1) was 43.97%. The purity of the compound has been tested using TLC, melting point and analytical HPLC. The identification of curcumin analog compound was analysed using UV, IR, 1H-NMR and MS. The toxicity test carried out by Brine Shrimps Lethality Test (BSLT) method to Artemia salina Leach larva showed LC50 higher than 200 ppm for the compound A1 with value of 995.40 ppm. The result of toxicity test showed that the compound A1 was not toxic.