SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI KALKON INTI NAFTALEN DARI ASETILNAFTALEN DAN 4-NITROBENZALDEHID

Abstract

Chalcon as synthetic compound or natural product had important biology activity. Biology activity of chalcone due to α, β unsaturated system. This research about synthesized a chalcone compound (E)-3-(4-nitrophenil)-1-(naphtalene-1-il)prop-2-en-1-on(AZ1) via aldol condensation reaction by using acetylnaphthalene and 4-nitrobenzaldehyde as precursor. The compound used KOH 6 N as catalyst. AZ had yields 73,02 % and characterized by UV spectroscopy, IR, 1H-NMR and 13C-NMR. The antibacterial activity determined by agar diffusion method in concentration 10 μg/disk and 30 μg/disk. The antibacteria test used Staphylococcus aureus and Bacillus subtilis (Gram positive bacteria), Escherichia coli and Salmonella enteritidis (Gram negative bakteria) as bacteria test