dc.contributor.author |
Simanjuntak, Jan Stepfely |
|
dc.date.accessioned |
2024-02-01T02:17:53Z |
|
dc.date.available |
2024-02-01T02:17:53Z |
|
dc.date.issued |
2023-09 |
|
dc.identifier.citation |
Perpustakaan |
en_US |
dc.identifier.other |
Elfitra |
|
dc.identifier.uri |
https://repository.unri.ac.id/handle/123456789/11266 |
|
dc.description.abstract |
Chalcone 1-(naphthalene-2-yl)-prop-2-en-1-on-3-(4-(2-morpholinetoxy)phenyl) (CLN-
2NFT-4OM) had been successfully synthesized via the Claisen-Schmidt reaction and
followed by O-alkylation. The morpholine substituted chalcone compound was
synthesized by stirring and heating at a temperature of 60-70°C for 14 hours and purified
by recrystallization to produce a pale white crystalline solid with a yield of 63.74%. The
structure of the target synthesis compound was analyzed and confirmed through UV,
FTIR, LCMS, 1H-NMR, and 13C- NMR. The in silico test was carried out on CLN-2NFT-
4OM (5) as a breast anticancer agent through molecular docking of the estrogen receptor
α (PDB ID:8DVB) with a positive control, namely 4-hydroxytamoxifen (4OHT). The
results of the anticancer activity of CLN-2NFT-4OM and the positive control respectively
through molecular docking analysis showed quite good inhibition of the estrogen receptor
α by showing binding free energy (ΔGbind) data and an inhibition constant of -9.4 kcal/mol
and 1.26 μM and -9.3 kcal/mol and 1.27 μM. These results are close enough between the
target compound and the positive control indicating that the compound chalcone CLN-
2NFT-4OM has the potential to act as an inhibitor of estrogen receptor α which triggers
as a cause of breast cancer. |
en_US |
dc.description.provenance |
Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2024-02-01T02:17:53Z
No. of bitstreams: 1
Jan Stepfely Simanjuntak_compressed.pdf: 175014 bytes, checksum: 2c47dccfaa699444ffa1e73644e96d89 (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2024-02-01T02:17:53Z (GMT). No. of bitstreams: 1
Jan Stepfely Simanjuntak_compressed.pdf: 175014 bytes, checksum: 2c47dccfaa699444ffa1e73644e96d89 (MD5)
Previous issue date: 2023-09 |
en |
dc.description.sponsorship |
Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riau |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elfitra |
en_US |
dc.subject |
anticancer |
en_US |
dc.subject |
chalcone |
en_US |
dc.subject |
morpholine |
en_US |
dc.title |
SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA KALKON 1- (NAFTALEN-2-IL)-PROP-2-EN-1-ON-3-(4-(2- MORFOLINETOKSI)FENIL) SEBAGAI KANDIDAT OBAT ANTIKANKER PAYUDARA |
en_US |
dc.type |
Article |
en_US |
dc.contributor.supervisor |
Jasril, Jasril |
|