AKTIVITAS ANTIDEPRESAN EKSTRAK n-HEKSANA BIJI PALA DENGAN METODA FORCED SWIM TEST PADA MENCIT JANTAN (Mus musculus)

Abstract

Depression is a disease associated with feelings of sadness and symptoms such as changes in sleep patterns, appetite, concentration and feelings of hopelessness. Depressive disorders can be experienced by adults and children can also experience depression regardless of social class. Pharmacological therapy for depressive disorders is a drug from the class of antidepressants. The method commonly used for antidepressant screening is the Forced Swim Test (FST). This study aims to determine the antidepressant activity of n-hexane extract of nutmeg through the FST method in an acute manner. FST is used because it is an in vivo method which can be a special test in basic and pre-clinical research. The injection was carried out intraperitoneally 1 hour before FST at a dose of 50 mg/kg and the control group was only injected with 0.9% saline. The n-hexane extract 50 mg/kg of nutmeg seed had no potential as an antidepressant as evidenced by the decrease in immobility time which was not significantly different from the control.