SINTESIS HIDRAZON (E)-2-((E)-3-(4-METOKSIFENIL)-1-(NAFTALEN- 1-IL)ALLILIDEN)-N-FENILHIDRAZINKARBOTIOAMIDA

Abstract

Hydrazone is an imine derivative compound that has an azomethin group (-NHN=CH) has various bioactivity such as anticancer agent. The hydrazone compound (E)-2-((E)- 3-(4-methoxyphenyl)-1-(naphthalene-1-yl)alliliden)-N-phenylhydrazinecarbotioamide has been successfully synthesized in a two step reaction. The reaction begins with the formation of chalcone (E)-3-(4-methoxyphenyl)-1-(naphtalene-1-yl)-prop-2-en-1-one by reacting 1-acetylnaphthalene and 4-methoxybenzaldehyde using the microwave method with a power of 180 watt. Then the chalcone is reacted with 4- phenylthiosemicarbazide to produce the target compound using a hydrochloric acid catalyst. The target compound synthesis method used is reflux at a temperature of 70- 80°C. The purity of the compound was determined using the TLC test, melting point, and HPLC analysis. The structure of the synthesized compound was confirmed by UV, FTIR, NMR, and HRMS spectroscopic studies. The result obtained from the synthesis of HDZ-1NFT-4FTS was 23.42%.