dc.contributor.author |
Novella, Dinda |
|
dc.date.accessioned |
2022-03-14T07:21:52Z |
|
dc.date.available |
2022-03-14T07:21:52Z |
|
dc.date.issued |
2021-09 |
|
dc.identifier.other |
wahyu sari yeni |
|
dc.identifier.uri |
https://repository.unri.ac.id/handle/123456789/10465 |
|
dc.description.abstract |
Miana (C. hybridus) is an ornamental plant that is widely used as a medicinal plant.
This study aimed to isolate secondary metabolites and test α-glucosidase inhibition from
these plants. Isolation was carried out by maceration method with methanol and then
partitioned with n-hexane solvent to obtain a thick n-hexane extract. Extracts were
separated by vacuum liquid chromatography (VLC) and purified by flash
chromatography. Two isolated pure compounds were obtained codenamed CHG-H7 and
CHG-H8 with melting points of 134º-136ºC and 136º-138ºC, characterized using FTIR
spectroscopy. α-Glucosidase inhibitory test was carried out using the α-glucosidase
enzyme and acarbose as positive controls. The results, it is known that the n-hexane
extract of C. hybridus has an IC50 value of 452.62 μg/mL with acarbose having an IC50
value of 68.410 μg/mL. The comparison of the IC50 value which is quite high between
the extract and acarbose can occur because in the tests carried out, the acarbose used is a
pure compound. Based on the results of the research that has been done, it can be
concluded that the n-hexane extract of C. hybridus has the potential as an enzyme
inhibitor α-glucosidase |
en_US |
dc.description.provenance |
Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2022-03-14T07:21:52Z
No. of bitstreams: 1
Dinda Novella_compressed.pdf: 183097 bytes, checksum: 5aa0ca8becc772ca8f4e32a0be6cd285 (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2022-03-14T07:21:52Z (GMT). No. of bitstreams: 1
Dinda Novella_compressed.pdf: 183097 bytes, checksum: 5aa0ca8becc772ca8f4e32a0be6cd285 (MD5)
Previous issue date: 2021-09 |
en |
dc.description.sponsorship |
Dosen Bidang Kimia Organik Bahan Alam Jurusan Kimia
Fakultas Matematika dan Ilmu Pengetahuan Alam |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
perpustakaan UR |
en_US |
dc.subject |
α-glucosidase |
en_US |
dc.subject |
Coleus |
en_US |
dc.subject |
isolation |
en_US |
dc.title |
ISOLASI SENYAWA METABOLIT SEKUNDER DAN PENGHAMBATAN α-GLUKOSIDASE DARI EKSTRAK n-HEKSANA TANAMAN MIANA HIJAU (Coleus hybridus) |
en_US |
dc.type |
Article |
en_US |
dc.contributor.supervisor |
Teruna, Hilwan Yuda |
|