Browsing by Author "Dewi, Gira Fitri"

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    SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-KLOROFENIL)-3- (NAFTALEN-2-IL)-1-FENIL-1H-PIRAZOL DARI PIRAZOLIN
    (2020-08) Dewi, Gira Fitri; Jasril, Jasril
    Pyrazole is a 5-ring heterocyclic compound which consist of 3 carbon atoms and 2 neighboring nitrogen atoms. This study was aimed to synthetized pyrazol compound and toxicity of the compound was determined by BSLT method. The pyrazole 5-(4- chlorophenyl)-3-(naphthalene-2-il)-phenyl-1H-pyrazole was synthesized through the oxidative aromatization reaction of pyrazolin compounds with glacial acetic acid. The synthesized compound was tested for purity using TLC, melting point and HPLC analysis. The structure of the synthesized compound was confirmed through UV spectroscopy and FTIR. The synthesis of pyrazole has the yield of 38,3%. Pyrazole was subjected to toxicity test through BSLT method using shrimp larvae (Artemia salina Leach). The pyrazole was toxic with LC50 value of 20,13 μg/mL.