SINTESIS ANALOG PIRAZOLIN 5-(4-FLOROFENIL)-3-(NAFTALEN-1-IL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL

Abstract

Pyrazoline analog compound, 5-(4-florophenyl)-3-(naphthalen-1-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (PF CN1-4F) has been synthesized through cyclization reaction between chalcone analog compound (E)-3-(4-florophenyl)-1-naphtalen-1-yl-propenone (CN1-4F) and phenylhidrazine using acetic acid glacial as catalyst with microwave. The purity of the compound was identified by TLC, and HPLC. Its structure was characterized using spectroscopy UV, IR, and MS. The pyrazoline analog compound was yellow crystals with a yield of 50.52%. Characterization result showed that it was our targetted compound.