UJI ANTIMIKROBA MEDIA FERMENTASI BATCH Penicillium sp. LBKURCC34

Abstract

Penicillium sp. LBKURCC34 is a fungi that isolated from peat soil of primary forest at Giam Siak Kecil Bukit Batu (GSKBB), Biosphere Reserve in Riau Province. The purpose of this study was to determine potency of this fungi as the source of antimicrobial compounds toward Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Candida albicans with dilution method. The metabolite compound production was done by fermentation in liquid medium for 14 days. Extract was evaporated and concentrated, then dissolved with dimethyl sulfoxide. Antimicrobial tests were carried out using resazurin dilution method using extract concentration of 4000 μl diluted to 7.8125 μl with positive controls Amoxsan® and Ketokonazol®. Unfortunately, due to inconsistency of resazurin reaction, the activity could not be calculated.