Abstract:
Abstract
Chronic obstructive pulmonary disease (COPD) is a progressive airway
obstruction, irreversible and often experience exacerbations because of bacterial
colonization has occurred. Management of COPD exacerbations are caused by
bacteria still rely on antibiotics to decrease mortality and morbidity rate. The
purpose of this study were to find out the pattern of the bacteria that cause COPD
exacerbation and it sensitivity to various antibiotics. Samples were sputum of
patients with COPD exacerbation Lung Poly and inpatients at RSUD Arifin Achmad.
Of the 30 sputum samples obtained 23 isolates of pathogenic bacteria and 9 non-
pathogenic bacterial isolates, 56.52% were Gram-positive and 43.47% were
Gram-negative bacteria. The pattern of bacterial isolates obtained were 12
coagulase negative Staphylococcus (37.50%), 1 isolate of Streptococcus pyogenes
(3.12%), 6 isolates of Pseudomonas aeruginosa (18.75%), 3 isolates of Klebsiella
spp (9.37%), 1 isolate of Escherichia coli (3.12%) and 9 isolates of Streptococcus
viridians (28.12%). The sensitivity test results showed Gram-positive bacteria
have the highest sensitivity to ciprofloxacin (30.77%), levofloxacin (23.08%),
cefotaxime and ertitromisin (7.69%) while the highest resistance to cefixime,
ceftriaxone, gentamicin, and amox-klav meropenem (100%). For Gram-negative
bacteria have the highest sensitivity was found to ciprofloxacin, levofloxacin, and
meropenem (40%) and cefepime (20%) while the highest resistance to cefixime,
cefotaxime, ceftriaxone, erythromycin, gentamicin and amox-klav
