Aktivitas Antibakteri Peptaibol Produksi Gliocladium sp T.N.C73

Abstract

Peptaibols are a unique class of peptides. They are characterized by molecular weights of 500- 2200 Da, a high number of non-proteinogenic, a,adialkylated a-amino acids like isovaline (Iva) and a-aminoisobutyric acid (Aib), an acetylated N-terminus, and an amino alcohol, mostly phenylalaninol, at the Cterminal end, which is lacking in the peptaibiotics. The name G peptaibol H originates from parts of the words peptide, Aib, and amino alcohol. Although peptaibols are not only produced by Trichoderma, most of the peptaibols known today have been found in this genus like Gliocladium sp. In metabolite production and extraction from Gliocladium sp. T.N.C73, it was harvested a few mycelium. TLC and detection of antibiotic compounds. MeOH extracts of Gliocladium sp T.N.C73 mycelium, were investigated for the presence of secondary metabolites including peptaibols by TLC. The separated compoimds, indentified as red spot. In this experiments, don't have red spot. Probability, dilute over sample.