SINTESIS ANALOG 2-PIRAZOLIN DARI KALKON INTI NAFTALEN DAN UJI AKTIVITASNYA SEBAGAI ANTIBAKTERI

Abstract

Pyrazolines have been reported to possess many of interesting biological activities such as antibacterial, antitumor, antioxidant, anti-inflammatory, antimalarial, anticancer, and anticonvulsant activity. In this research, an analog pyrazoline 5-(4-chlorophenyl)-3-(naphthalene-1-yl)-4,5-dihydro-1H-pirazol was synthesized by the reaction between 1-naphthyl chalcones and hydrazine hydrate using glacial acetic acid as catalyst under microwave irradiation. The compound showed a good yield, and then was characterized by UV, IR and 1H-NMR spectroscopy. The antibacterial activity of this compound was determined using agar diffusion method against the bacteria Escherichia coli, Salmonella typi, Bacillus subtilis and Staphylococcus aureus. The antibacterial activity were classified as very weak at concentrations of 10, 30 and 50 μg/disk with a diameter of inhibition produced of 6,2 – 8,1 mm.