SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KURKUMIN (3E,5E)-3,5-BIS(2’-HIDROKSIBENZILIDIN) -1-METILPIPERIDIN-4-ON

Abstract

The derivatives of curcumin are secondary metabolites belonging to the phenolic group. Some of them were reported to have biological activities such as antiinflammatory, anticancer and antioxidant activities. In this study, a curcumin of (3E,5E)-3,5-bis(2’-hidroxybenzilidin)-1-metilpiperidin-4-one from 1-methyl-4- piperidinone with 2-hydroxy benzaldehide has been successfully synthesized using microwave irradiation method with NaOH (20%) as catalyst. Reaction was carried out for 1 minute at 180 watt. The compound resulted was in the form of yellow crystal with a yield of 72%. The compound was characterized by measuring its melting point, identifying by TLC, and elucidated by UV-Vis, FT-IR, MS, 1H NMR, and 13C NMR. Our result showed that the compound had the targeted molecule structure. Antibacterial test was carried out using the agar diffusion method against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Salmonella enteritidis. Overall, inhibition zone ranged from 6.5 to 10 mm and showed a very weak activity.