SINTESIS DAN UJI TOKSISITAS SENYAWA KALKON ANALOG 2,5-DIMETOKSIBENZALDEHID

Abstract

Chalcones are a class of α,ß-unsaturated carbonyl compounds that forms the central core of various naturally occurring biologically active compounds. They exhibit tremendous potential to act as a pharmacological agent. It has been reported that they were active as antioxidant, antifungal, antibacterial, antidepressant, anticancer, anti-inflammatory and other biological activities. The chalcone analogue of 2,5-dimetoxibenzaldehyde ((E)-3-(2,5-dimetoksifenil)-1-(4-hidroksifenil)prop-2-en-1-on) was synthesized and tested for its toxicity using Brine Shrimp Lethality Test (BSLT) method. The purity of compound has been tested using TLC, melting point test, analytical HPLC. It was then characterized using UV, IR, 1H-NMR and MS spectroscopy. LC50 value of toxic compound is <200μg/mL. Our result showed that (E)-3-(2,5-dimetoksifenil)-1-(4-hidroksifenil)prop-2-en-1-on compound was not potential as an anticancer since its LC50 was 1949 μg/mL.