Abstract:
The number of structure of carbonoylarylthiourea derivatives is increasing because of their
potential in biological properties. The structural informations are important for the structureactivity
relationship studies or rational drug design work. However, the thioureas containing
halogen in the carbonoyl fragment is still very scarce. N-(3-chloropropionyl)-N'-(2-
methylphenyl)thiourea(I) and N-(3-chloropropionyl)-N'-(4-methylphenyl)thiourea(II) were
synthesized and characterized by FTIR and NMR spectroscopic techniques. The compound (I) was
obtained as twinned crystal. The X-ray study showed that the asymmetric unit consists two
independent molecules. The trans–cis configuration of the chloropropionyl and methyl phenyl
groups respectively, against the thiono about their C-N bonds is maintained
