dc.contributor.author |
Nurwantari, W. |
|
dc.contributor.author |
Eryanti, Y. |
|
dc.contributor.author |
Jasril |
|
dc.contributor.author |
Zamri, A. |
|
dc.date.accessioned |
2014-03-27T07:14:08Z |
|
dc.date.available |
2014-03-27T07:14:08Z |
|
dc.date.issued |
2014-03-27 |
|
dc.identifier.other |
Rangga Dwijunanda Putra |
|
dc.identifier.uri |
http://repository.unri.ac.id/xmlui/handle/123456789/5955 |
|
dc.description.abstract |
Curcumin is one of secondary metabolites included into the fenolic group which was known to have various of biological activities such as antimicroba, anticancer, antioxidance, antitumor and anti-inflammatory. Therefore, curcumin through the variation of thestructurecould became amodel for target molecule. In this research, curcumin analog coumpond of 4-piperidone derivative was synthesized using
microwave irradiation withan acid catalyst (SOCl2). The rendement resultedfrom curcumin analog is(3E,5E)-3,5-bis (2-chlorobenzilidyn)-piperidyn-4-one(1) 94,35%.
The purity ofompoundhas been tested using TLC, melting pointtest, and analytical HPLC.The compoundresulted was characterized usingUV, IR, 1 H NMR and 13 C NMR.The toxicity test done by Brine ShrimpLethality Test(BSLT) method toArtemia salinaLeach larvagaveLC50 value< 200 μg/mL.The resultshowedthatcompound(1) haspotential asananticancerwithLC50 value= 55,46µg/mL. |
en_US |
dc.description.provenance |
Submitted by Rangga Dwijunanda Putra (rangga.madridista@gmail.com) on 2014-03-27T07:14:08Z
No. of bitstreams: 1
KARYA ILMIAH WINA NURWANTARI.pdf: 81910 bytes, checksum: 573fd2cdd91f351b63d1ca5bb1f9416f (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2014-03-27T07:14:08Z (GMT). No. of bitstreams: 1
KARYA ILMIAH WINA NURWANTARI.pdf: 81910 bytes, checksum: 573fd2cdd91f351b63d1ca5bb1f9416f (MD5) |
en |
dc.description.sponsorship |
Eryanti, Y., Jasril., Zamri, A |
en_US |
dc.language.iso |
other |
en_US |
dc.subject |
Brine Shrimp Lethality Test(BSLT) |
en_US |
dc.subject |
curcumin |
en_US |
dc.subject |
toxicity test |
en_US |
dc.title |
SINTESISDAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 4-PIPERIDINON |
en_US |
dc.type |
Other |
en_US |