SINTESIS ANALOG KURKUMIN TURUNAN 1-BENZIL 4-PIPERIDINON MENGGUNAKAN KATALIS BASA DAN UJI AKTIVITAS SEBAGAI ANTIBAKTERI

Abstract

Curcumin is one of secondary metabolites with phenolic group which was known to have various biological activities such as antimicroba, anticancer, antioxidant, antitumor and anti-inflammatory activities. In this research, curcumin analog of 1-benzil-4- piperidone derivative was synthesized using microwave irradiation with catalyst NaOH. The rendement (YN2) resulted 99.39%. All compounds were characterized using UV spectrophotometer, IR spectrophotometer, 1 H NMR, and 13 C NMR spectrometers. The antibacterial activity was evaluated using the agar diffusion method. Antibacterial activity test was carried out at concentrations of 20, 30, 40, 50 , and 60 mg/disc against Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram negative bacteria (Escherichia coli and Salmonella enteritidis). YN 2 compounds obtained showed different antibacterial activity against different bacteria.