SINTESIS DUA ANALOG 4’-BROMO CALKON MELALUI KONDENSASI ALDOL DAN UJI ANTIOKSIDAN METODE FERI TIOSIANAT

Abstract

Chalcons are precursors of open chain flavonoids and isoflavonoids present in edible plants. Their derivatives have become attention for researchers because of their potentioal pharmacological effects. In finding of new efficient antioxidant compounds, substituted-chalcones have been synthesized by condensing benzaldehyde derivatives with 4’-bromoacetophenone in conventional method at room temperature based on Claisen-Schmidt condensation on alkali condition. The structures of the compounds were characterized by using infra red and nuclear magnetic resonance spectroscopy. In terms of antioxidant activity by using ferric thiocyanate (FTC) method, the compounds showed moderate antioxidant activity