SINTESIS DAN UJI TOKSISITAS BEBERAPA SENYAWA ANALOG PARA METOKSI KALKON

Abstract

Chalcone is a very interesting compound because it is known to have various of biological activities such as antimicroba, antifungi, anesthetics, anticancer, antimalaria, antioxidance, antitumor and anti-inflammatory. Moreover, natural and synthetic compounds of chalcone have roles as precursors for other compounds. Therefore, many chalcones become model structures of target compounds by researcher. In this research, chalcone methoxy analogue compounds have been synthesized using stirer method and using base catalyst NaOH. The synthesized results obtained are (E)-3-(4- isopropylphenyl)-1-(4'-methoxyphenyl)prop-2-en-1-one (1), (E)-1-(4'-methoxyphenyl)- 3-p-tolylprop-2-en-1-one (2) and (E)-3-(3-bromophenyl)-1-(4'-methoxyphenyl)prop-2- en-1-one (3). The purity of all compounds have been tested using TLC, melting point test, analytical HPLC. Then they are characterized using UV, FTIR, 1H-NMR and MS spectroscopy. The toxicity test of the novel compounds was done by Brine Shrimp Lethality Test (BSLT) method. The all compounds showed very good activity with LC50 value < 200 μg/mL