AKTIVITAS ANTIDEPRESAN EKSTRAK ETIL ASETAT BIJI PINANG TUA DENGAN METODA FORCED SWIM TEST PADA MENCIT JANTAN (Mus musculus)

Abstract

Depression is a mental disorder characterized by a persistently lowered mood and leads to patients experiencing decreased productivity and even ending in suicide. Antidepressants can be used for the initial treatment of depressed patients. Herbs has potential as antidepressants that can be selected using the Forced Swim Test (FST) method. This study aims to determine the antidepressant activity of the ethyl acetate extract of old areca nut seeds through the FST method in an acute manner. FST was used because it was one of the most widely used in vivo methods for antidepressant screening in basic and preclinical studies. Intraperitoneal injection of mice was performed 1 hour before FST at a dose of 10 mg/kg and the control group was injected with 0.9% saline only. Ethyl acetate extract of old areca nut seeds dose of 10 mg/kg was not effective as an antidepressant because the decrease in immobility time was not significantly different to control.