Abstract:
Kelakai, also known as Stenochlaena palustris, is a fern that is commonly used as a
medicinal plant for its antioxidant, antimicrobial, antianemia, and antidiabetic
properties. The purpose of this study was to observe the activity of extracts and ethyl
acetate fractions of S.palustris in its ability as inhibitor of the α-glucosidase enzyme. A
plant is said to have good antidiabetic activity if it has an IC value50 below 100 μg/mL.
According to the results of the in vitro antidiabetic test α-glucosidase inhibitory assay
on the α-glucosidase enzyme performed, the ethyl acetate extract has an IC value50 of
37.57 μg/mL. Meanwhile, for the extraction results of ethyl acetate extract S.palustris
using the vacuum liquid chromatography (VLC) method, 5 fractions were produced and
only fractions 5 had good anti-diabetic activity, which had an IC value50 141,31 μg/mL.
