AKTIVITAS ANTIDEPRESAN EKSTRAK METANOL BIJI PINANG MUDA DENGAN METODA FORCED SWIM TEST PADA MENCIT JANTAN (Mus musculus)

Abstract

Depression is a mood disorder in the form of deep depressing emotions or feelings. Depressive disorders often occur in society and become the biggest contributor to suicide. The main pharmacological therapy for depressive disorders is antidepressant drugs. The Forced Swim Test (FST) method is a method commonly used for antidepressant screening. This study aims to determine the antidepressant activity of young areca seed methanol extract through the FST method in an acute manner. The in vivo FST method was chosen because it can be a specific test to measure behavior that is common for antidepressant treatments that have pharmacological effects. The injection was carried out intraperitoneally 1 hour before FST at a dose of 10 mg/kg and the control group was only injected with 0.9% saline. The methanol extract of 10 mg/kg of young areca nut seeds has no potential as an antidepressant as evidenced by the absence of a significant decrease in immobility time compared to the control.