Abstract:
Endophytic fungi are microorganisms that are able to form colonies in plant tissues
without posing a threat to their hosts and that live in plant tissue systems at certain times.
Botryosphaeria rhodina, isolated from mangroves in the Muara Sungai Siput region of
the Bengkalis Regency, is one of the endophytic fungi with high biological activity. This
study aims to isolate secondary metabolites from the extract of the endophytic fungus B.
rhodina and assess their antifungal activity against Candida albicans. The microdilution
method was used to determine the MIC (minimum inhibitory concentration) value, while
the agar diffusion method was used to determine the MFC (minimum fungicidal
concentration) value. Methanol and n-hexane extracts with concentrations of 1,000, 500
and 250 μg/mL were used as test samples. The results of the antifungal test revealed that
the MIC values of the n-hexane extract, methanol extract, and MFC were 1,000 μg/mL,
500 μg/mL and 1,000 μg/mL, respectively, against C. albicans.
