SINTESIS 5-(2-METOKSIFENIL)-3-(2-HIDROKSINAFTALEN-1-IL)- 1-FENIL-4,5 DIHIDRO-1H-PIRAZOL

Abstract

Pyrazoline is five-ring heterocyclic compounds composed of three carbon atoms and two nitrogen atoms that are close together. The aim of this study was to synthesize naphthalene core pyrazoline compounds with hydroxy and methoxyphenyl groups on the pyrazoline ring. The compound 5-(2-methoxyphenyl)-3-(2-hydroxynaphthalen-1-yl)-1- phenyl-4,5-dihydro-1H-pyrazole (PRZ-2OCH3) was synthesized through two reaction steps. The first step is the reaction of 2-hydroxy-1-acetylnaphthalene and 2-methoxy benzaldehyde with NaOH 3N catalyst to give the compound 3-(2-methoxyphenyl)-1-(2- hydroxynaphthalen-1-yl)-2-propen-1-on. Produces a yield of 90.8%. Further, this chalcone was reacted with phenylhydrazine over a KOH 3N catalyst to give a yield of 72%. The target pyrazoline compounds were tested by TLC, melting point and HPLC analyses. Compounds were analyzed by UV-Vis spectrophotometer and FTIR