SINTESIS 5-(2-FLUOROFENIL)-3-(2-HIDROKSINAFTALEN-1-IL)- 1-FENIL-4,5-DIHIDRO-1H-PIRAZOL

Abstract

Pyrazoline is a five-membered heterocyclic compound with three carbon atoms and two adjacent nitrogen atoms within the ring. Pyrazoline 5-(2-fluorophenyl)-3-(2-hydroxy naphthalen-1-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (PR-NH2-2F) had successfully synthesized by using two-steps, the first step of producing chalcone by reacting an aldehyde and a ketone involves the aldol condensation reaction, then producing pyrazoline by cyclization reaction between chalcone and phenylhydrazine. Synthesis of the pyrazoline by using monowave, at a temperature of 800C for 2 hours. The yield of the synthesis PR-NH2-2F compound was 52,35%. The purity of the compound was determined using TLC, melting point, and HPLC. The structure of synthesized compound was confirmed by ultraviolet (UV) and fourier transform infra-red (FTIR) spectroscopy data analysis.