dc.contributor.author |
Sari, Ajeng Defa Risqina |
|
dc.date.accessioned |
2022-10-17T08:01:00Z |
|
dc.date.available |
2022-10-17T08:01:00Z |
|
dc.date.issued |
2022-07 |
|
dc.identifier.citation |
Perpustakaan |
en_US |
dc.identifier.other |
Elfitra |
|
dc.identifier.uri |
https://repository.unri.ac.id/handle/123456789/10716 |
|
dc.description.abstract |
Green-red miana plant (Coleus hybridus) is an ornamental plant that is widely used as a
medicinal plant. This plant belongs to genus Coleus and the family Lamiaceae. The goal
of this study was to isolate secondary metabolites of green-red miana (Coleus hybridus)
and analyze the inhibition activity of α-glucosidase by in vitro method. This plant was
extracted using maceration method with methanol and partitioned with n-hexane and
ethyl acetate. The separation of n-hexane extract was carried out using vacuum liquid
chromatography followed by separation using flash chromatography. Purity of the
compound was analyzed using TLC and melting point 138-140oC. The solids were
recrystallized to obtain white crystalline solids with weight of 90,36 mg
(coded CHHM-H-V4-FL14). Characterization of the solids using FTIR spectroscopy
showed the presence of OH groups, aliphatic CH, methyl (CH3) C=C cyclic alkenes and
CO. The result of the characterization with the FTIR as well as phytochemical analysis
of the CHHM-H-V4-FL14 were assumed to be a steroid secondary metabolites.
Analysis of the inhibition of the α-glucosidase enzyme revealed that the CHHM-H-V4-
FL14 percentage of inhibition was 8.441% while the percentage of acarbose inhibition
(positive control) was 99.492%. It is estimated that the green-red miana
(Coleus hybridus) possesses weak inhibition activity against the α-glucosidase enzyme. |
en_US |
dc.description.provenance |
Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2022-10-17T08:01:00Z
No. of bitstreams: 1
Ajeng Defa Risqina Sari_compressed.pdf: 164406 bytes, checksum: 1a9a50a5b70050f5f525673cae915b91 (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2022-10-17T08:01:00Z (GMT). No. of bitstreams: 1
Ajeng Defa Risqina Sari_compressed.pdf: 164406 bytes, checksum: 1a9a50a5b70050f5f525673cae915b91 (MD5)
Previous issue date: 2022-07 |
en |
dc.description.sponsorship |
Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riau |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elfitra |
en_US |
dc.subject |
α-glucosidase |
en_US |
dc.subject |
Coleus |
en_US |
dc.subject |
isolation |
en_US |
dc.subject |
spectroscopy |
en_US |
dc.title |
ISOLASI DAN UJI PENGHAMBATAN α-GLUKOSIDASE METABOLIT SEKUNDER EKSTRAK n-HEKSANA TANAMAN MIANA HIJAU-MERAH (Coleus hybridus) |
en_US |
dc.type |
Article |
en_US |
dc.contributor.supervisor |
Teruna, Hilwan Yuda |
|