dc.contributor.author |
Angriana, Oktasalisa |
|
dc.date.accessioned |
2022-06-15T06:41:26Z |
|
dc.date.available |
2022-06-15T06:41:26Z |
|
dc.date.issued |
2021-12 |
|
dc.identifier.citation |
Perpustakaan |
en_US |
dc.identifier.issn |
Elfitra |
|
dc.identifier.uri |
https://repository.unri.ac.id/handle/123456789/10528 |
|
dc.description.abstract |
Pyrazoline and pyrazole are heterocyclic compounds containing two nitrogen atoms which have
various bioactivities such as antidiabetic, anticancer, antibacterial, and tyrosinase inhibitors.
Pyrazoline compounds and pyrazole derivatives of 2-methoxyphenyl and
3-hydroxybenzaldehyde was synthesized in three steps. The first stage is the formation of
chalcone compounds using a microwave device, the second stage is the formation of pyrazoline
compounds using a monowave device, and the third stage is the formation of pyrazole
compounds using a reflux device. The purity of the target compound was then analyzed by TLC
test, melting point measurement, and HPLC. The synthesized compound was then confirmed by
its structure through UV spectroscopy, FTIR, 1 H-NMR, and HRMS. These compounds were
tested for their activity as tyrosinase inhibitors through molecular docking and in vitro tests. The
activity of the target compound was compared with kojic acid as a positive control. The test
results through molecular docking showed that the pyrazoline target compound had a free bond
energy (S score) = -11.0581 kcal/mol while the pyrazole target compound had a free bond energy
(S score) = -11.0446 kcal/mol. If viewed from the positive control, namely kojic acid which has
a bond free energy (S score) = -8.7148 kcal/mol, the synthesized pyrazoline and pyrazole
compounds have the potential as tyrosinase inhibitor compounds. In vitro test results showed that
the target compound pyrazoline had an IC50 value of 1282,023 μg/mL while the pyrazole
compound had an IC50 value of 217.434 μg/mL, and kojic acid compounds had an IC50 value of
12.58 μg/mL, pyrazoline and pyrazole compounds. Synthesized pyrazoline and pyrazole
compounds are weak inhibitors in inhibiting the tyrosinase enzyme because pyrazoline and
pyrazole compounds have not been able to match kojic acid in inhibiting the tyrosinase enzyme. |
en_US |
dc.description.provenance |
Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2022-06-15T06:41:26Z
No. of bitstreams: 1
Oktsalisa Angriana_compressed.pdf: 292929 bytes, checksum: 9b7ca96aa3de6c8b0dc5404ef3f34abc (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2022-06-15T06:41:26Z (GMT). No. of bitstreams: 1
Oktsalisa Angriana_compressed.pdf: 292929 bytes, checksum: 9b7ca96aa3de6c8b0dc5404ef3f34abc (MD5)
Previous issue date: 2021-12 |
en |
dc.description.sponsorship |
Jurusan Kimia
Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riau |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elfitra |
en_US |
dc.subject |
docking |
en_US |
dc.subject |
pyrazole |
en_US |
dc.subject |
pyrazoline |
en_US |
dc.subject |
synthesis |
en_US |
dc.title |
SINTESIS, UJI AKTIVITAS DAN MOLECULAR DOCKING SENYAWA PIRAZOLIN DAN PIRAZOL TURUNAN 2-METOKSI FENOL DAN 3-HIDROKSIBENZALDEHID TERHADAP INHIBITOR ENZIM TIROSINASE |
en_US |
dc.type |
Article |
en_US |
dc.contributor.supervisor |
Zamri, Adel |
|