dc.contributor.author |
Ningsih, Winda Ayu |
|
dc.date.accessioned |
2022-03-15T03:40:35Z |
|
dc.date.available |
2022-03-15T03:40:35Z |
|
dc.date.issued |
2021-10 |
|
dc.identifier.other |
wahyu sari yeni |
|
dc.identifier.uri |
https://repository.unri.ac.id/handle/123456789/10497 |
|
dc.description.abstract |
Pyrazoline is a five-ring heterocyclic compound which has two nitrogen atoms close
together in the ring and has only one endocyclic double bond. Pyrazoline analogue
5-(4-fluorophenyl) -3- (2-hydroxynaphthalene-2-yl) -1-phenyl-4,5-dihydro-1H-pyrazole
(PF-NH2-4F) is synthesized by cyclization reaction of chalcone compounds
3-(4-fluorophenyl) -1- (2-hydroxy naphthalene -2-yl) -2- propen -1-one with phenyl
hydrazine. Synthesis of the pyrazoline using monowave, at a temperature of 80oC for 2
hours. The purity of the compound was determined using TLC test, melting point
measurement and HPLC analysis. The structure of the synthesized compound was
confirmed by means of UV-Vis and FTIR. The yield resulting from the synthesis of the
compound PF-NH2-4F was 47.42%. The activity test of pyrazoline compounds was
determined by the BSLT method using shrimp larvae (Artemia salina Leach) which
obtained an LC50 value of 7.88 μg/mL, which are considered to have moderate levels of
toxicity due to their toxicity activity have LC50 values >1 μg/mL and <100 μg/mL |
en_US |
dc.description.provenance |
Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2022-03-15T03:40:35Z
No. of bitstreams: 1
Winda Ayu Ningsih _compressed.pdf: 204777 bytes, checksum: 2bd8bd0e2a1cfb66d99ea04966419d3b (MD5) |
en |
dc.description.provenance |
Made available in DSpace on 2022-03-15T03:40:35Z (GMT). No. of bitstreams: 1
Winda Ayu Ningsih _compressed.pdf: 204777 bytes, checksum: 2bd8bd0e2a1cfb66d99ea04966419d3b (MD5)
Previous issue date: 2021-10 |
en |
dc.description.sponsorship |
Dosen Bidang Kimia Organik Jurusan Kimia
Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riau |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
perpustakaan UR |
en_US |
dc.subject |
monowave |
en_US |
dc.subject |
pyrazoline |
en_US |
dc.subject |
toxicity |
en_US |
dc.title |
SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-FLOROFENIL)-3-(2- HIDROKSINAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL |
en_US |
dc.type |
Article |
en_US |
dc.contributor.supervisor |
Jasril, Jasril |
|