SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-FLOROFENIL)-3-(2- HIDROKSINAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL

Abstract

Pyrazoline is a five-ring heterocyclic compound which has two nitrogen atoms close together in the ring and has only one endocyclic double bond. Pyrazoline analogue 5-(4-fluorophenyl) -3- (2-hydroxynaphthalene-2-yl) -1-phenyl-4,5-dihydro-1H-pyrazole (PF-NH2-4F) is synthesized by cyclization reaction of chalcone compounds 3-(4-fluorophenyl) -1- (2-hydroxy naphthalene -2-yl) -2- propen -1-one with phenyl hydrazine. Synthesis of the pyrazoline using monowave, at a temperature of 80oC for 2 hours. The purity of the compound was determined using TLC test, melting point measurement and HPLC analysis. The structure of the synthesized compound was confirmed by means of UV-Vis and FTIR. The yield resulting from the synthesis of the compound PF-NH2-4F was 47.42%. The activity test of pyrazoline compounds was determined by the BSLT method using shrimp larvae (Artemia salina Leach) which obtained an LC50 value of 7.88 μg/mL, which are considered to have moderate levels of toxicity due to their toxicity activity have LC50 values >1 μg/mL and <100 μg/mL