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SINTESIS DAN UJI TOKSISITAS SENYAWA N’1,N’3-BIS ((E,Z)-4- FLUOROBENZILIDEN)MALONOHIDRAZID

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dc.contributor.author Dewi, Ratna Reski
dc.date.accessioned 2022-03-15T02:42:03Z
dc.date.available 2022-03-15T02:42:03Z
dc.date.issued 2021-10
dc.identifier.other wahyu sari yeni
dc.identifier.uri https://repository.unri.ac.id/handle/123456789/10490
dc.description.abstract Hydrazone is a versatile compound in drug design for the synthesis of heterocyclic compounds with different biological activities because it has two active centers, namely two nitrogen atoms and two carbon atoms. The combination of hydrazones with other functional groups produces compounds with unique physical and chemical properties. The addition of a fluoro group in a compound can have a significant effect and can increase the activity of the compound. Some of the pharmacological activities of hydrazone compounds include antimicrobial, antiviral, anticancer and others. The aim of this study was to synthesize the compound N'1,N'3-bis((E, Z)-4-fluorobenzyliden) malonohydrazide which has a good toxicity value. The compound N'1,N'3-bis((E,Z)-4-fluorobenzyliden) malonohydrazide was synthesized by condensation reaction between malonohydrazide and 4-fluoro benzaldehyde using glacial acetic acid as catalyst. Synthesis of compound N'1,N'3- bis((E, Z)-4-fluorobenzyliden) malonohydrazide using reflux with heating and stirring method. The purity test for this compound was determined using the TLC test, melting point determination and HPLC analysis. The structure of the compound was identified using spectroscopic analysis of UV and FTIR. The yield obtained from the synthesis was 67.79%. The toxicity test of the compound was carried out using the Brine Shrimp Lethality 2 Test (BSLT) method and the results showed that this compound was toxic with an LC value of50 = 125.02 g/mL. en_US
dc.description.provenance Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2022-03-15T02:42:03Z No. of bitstreams: 1 Ratna Reski Dewi Nasution_compressed.pdf: 221399 bytes, checksum: 7d8400d467bb7968825e1ff20232fa7e (MD5) en
dc.description.provenance Made available in DSpace on 2022-03-15T02:42:03Z (GMT). No. of bitstreams: 1 Ratna Reski Dewi Nasution_compressed.pdf: 221399 bytes, checksum: 7d8400d467bb7968825e1ff20232fa7e (MD5) Previous issue date: 2021-10 en
dc.description.sponsorship Dosen Jurusan Kimia FMIPA Universitas Riau Fakultas Matematika dan Ilmu Pengetahuan Alam en_US
dc.language.iso en en_US
dc.publisher perpustakaan UR en_US
dc.subject BSLT en_US
dc.subject fluoro en_US
dc.subject hydrazone en_US
dc.title SINTESIS DAN UJI TOKSISITAS SENYAWA N’1,N’3-BIS ((E,Z)-4- FLUOROBENZILIDEN)MALONOHIDRAZID en_US
dc.type Article en_US
dc.contributor.supervisor Jasril, Jasril


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