EFEK EKSTRAK SELEDRI (Apium graveolens L.Var. Sylvester) TERHADAP KADAR ASAM URAT TIKUS PUTIH (Rattus novergicus Berkenhout 1769) GALUR WISTAR

Abstract

Celery (Apium graveolens L. Var. Sylvester) is an herb that has the potential as an alternative traditional medicine for anti-hyperuricemia because it contains flavonoids, 3-n butylphthalide, and vitamin C, which can inhibit the action of the Xantin Oxidase enzyme that acts as catabolism of purines into uric acid. The aim of this study was to test the celery extract at various doses to reduce uric acid levels in male white rats. This study consisted of K- (aspirin 12.6 mg/kg BW), K + (normal feed), P (celery extract 100 mg/kg BW + aspirin 12.6 mg/ kg BW). The results of the study concluded that celery extract affected uric acid levels. P treatment with a dose of 100 mg/kg BW can reduce uric acid levels from 8.70 mg / dl to 4.53 mg/dl.