SINTESIS DAN UJI TOKSISITAS SENYAWA 1-(NAFTALEN-1- ILMETILEN)-2-FENILHIDRAZIN

Abstract

Hydrazone is an organic compound that has a variety of biological activities such as antioxidant and anticancer. The active group of hydrazone compound the azomethine group (-NHN=CH-) makes this compound as an important compound in the development of new drugs. Hence, in this study, the synthesis of hydrazone 1-(naphthalene-1-ylmetilen)-2-phenylhydrazine (IFA-ND1) was obtained from the condensation reaction between 1-naphthalene and phenylhydrazine catalyzed by acetic acid. This compound was synthesized compound by microwave irradiation method at 180 Watt. The purity of the compound is determined by using thin layer chromatography and melting point. The structure of the synthesized compound was characterized by the spectrum of UV and FTIR. The bioactivity of the IFA-ND1 compound was evaluated with its toxicity properties by BSLT method with a value of LC50 = 1.455 μg/mL. This suggests that the IFA-ND1 compound is a potential compound with toxic properties