SINTESIS DAN UJI TOKSISITAS SENYAWA 1,2-BIS(NAFTALEN- 1-ILMETILEN)HIDRAZIN

Abstract

Hydrazone is a versatile organic compound that has a basic structure (R1R2C=N-NR3R4). The active center of hydrazone are carbon and nitrogen atoms. The active group of the hydrazone compound is azomethine (-NHN=CH-), which makes this compound the most important in the development of new medicines. In this research, the synthesis of the compound hydrazine 1,2- bis(naphthalene-1-ilmethylene)hydrazine (IHA-ND1) obtained from the condensation reaction between the 1-naphthaldehyde and hydrazine hydrate catalyzed by acetic acid. This compound was synthesized using a microwave irradiation method with 180 Watt. The purity of the compound was determined by TLC and melting point measurement. The structure of the synthesized compound was confirmed through spectroscopic UV and FTIR analysis. The results of this research were the IHA-ND1 compound successfully synthesized with a 54,87% yield. The bioactivity of the IHA-ND1 compound was evaluated its toxicity properties by the BSLT method using shrimp larvae (Arthemia salina Leach). LC50 value of compounds IHAND1 is 47,20 μg/mL. It can be concluded that the compound IHA-ND1 is toxic, and further pharmacological tests can be carried out