Sari, Rika PurnamaRoza, Rodesia MustikaFitmawati2013-03-042013-03-042013-03-04Rangga Dwijunanda Putrahttp://repository.unri.ac.id:80/handle/123456789/2405Many kinds of plant species grow in Indonesia. One of them is Mahang (Macaranga triloba (Muell.) Arg.). Mahang (Macaranga triloba (Muell.) Arg.) leaf are often used as traditional medicine. The aims of this study were to find the activity of bacterias using 4 extraction methods and to find the most effective extraction method and concentration in inhibition the bacteria growth againts E. coli and S. typhi. The extraction which had been done by maceration method with methanol dissolver, boiling dry leaf, grinding leaf, boiling fresh leaf. The testing activity was done using paper disk and agar well by extract concentration 100%, 75%, 50%, 25% and 10%. The result of this research showed that of the most effective extraction method and concentration in producing inhibition zone were methanol in concentration of 100%, both E. coli and S. typhi, that is 15,43±2,19 mm and 20,67±1,14 mmotherantibacteriaEscherichia coliextractMacaranga trilobaSalmonella typhiOther