Novianti, S2015-03-232015-03-232015-03-23wahyu ari yenihttp://repository.unri.ac.id/xmlui/handle/123456789/6885Chalcones belong to important class of flavonoid compounds. They have also been reported to have anticancer, antimicrobial, antifungal, antioxidant, and cytotoxic activities. In this research, an analogous chalcone of (E)-3-(4-clorophenyl)-1-(3’,4’- dimetoxyphenyl) prop- 2-en-1-on was synthesized using microwave iradiation and natrium hidroxide as catalyst. The compound showed a good yield, and then was characterized by UV spectroscopy, IR, 1H-NMR, and Mass Spectroscopy. Its toxicity has been identified using Brine Shrimp Lethality Test (BSLT) method on Artemia salina Leach. The result showed that it had a good toxicity activity with LC50 = 2.24 μg/ mL and potential as anticanceren3’, 4’dimetoxyacetophenoneBSLTchalcones, toxicityUR-Student Paper Diploma