Hasanah, U.Zamri, A.Balatif, N.Eryanti, Y.2014-03-272014-03-272014-03-27Rangga Dwijunanda Putrahttp://repository.unri.ac.id/xmlui/handle/123456789/5953The derivatives of curcumin are second ary metabolites belonging to the phenolic group. Some of them were reported to have biological activities such as anti -i nfl ammatory, anticancer and antioxidant activities. In this study, acurcumin of (3E,5E)-3,5bis(2’-hidroxybenzilidin)-1-metilpiperidin-4-one from 1-methyl-4-pi peridinone with 2-hydroxy benzaldehideh as been successfully synthesized using microwave irradiation method with NaOH (20 %) as catalyst . React ion was carried out for 1 minute at 180 watt . The compound resulted was in the form of yellow crystal withayield of 72 %. The compound was characterized by measuring its melting point, identifying by TLC, and elucidated by UV-Vis, FT- IR, MS, 1 H NMR, and 13 C NMR. Our result show edthatthecom pound had the target edmolecule structure. Ant i bacterial test was carried out using the agar di ffusion method against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Salmonella enteritidis. Overall, inhibition zone ran ged from 6.5 t o 10 mm and showed avery weak activity.other1-methyl-4-piperidinone2-hydroxy benzaldehideantbacterialcurcuminOther