Rahmawati, Siti2023-02-172023-02-172022-11PerpustakaanElfitrahttps://repository.unri.ac.id/handle/123456789/10860Hydrazone is an imine-derived compound that has various biological activities, such as anticancer, antimalarial, antimicrobial, and antioxidant,. Hydrazone compound (E)-N'- ((E)-3-(4-methoxyphenyl)-1-(naphthalen-1-il)alliliden)-4-methylbenzensulfonohidrazid (HDZ-1-NFT-4-TSH) has been successfully synthesized. Begins with the formation of chalcone (E)-3-(4-methoxyphenyl)-1-(naphtalene-1-yl)-prop-2-en-1-one by reacting 1-acetylnaphtalene and 4-methoxybenzaldhyde with KOH 3N as catalyst then produced yield 29.70%. The next step was reacted chalcone and p-toluensulfonyl hydrazine with HCl 3N as catalyst then produced yield 77.87%. The hydrazone compound was tested with TLC test, melting point and HPLC analysis. The compound was analyzed by UV-Vis and FTIR spectrophotometer. The toxicity of the compound was evaluated by BSLT (brine shrimp lethality test) method using Artemia salina Leach larvae. The test results showed that the hydrazone compound was non-toxic with LC50 value of 251,18 μg/mL.enhydrazonesynthesistoxicityArticle