Novianti, S.Balatif, N.Zamri, A.2014-03-272014-03-272014-03-27Rangga Dwijunanda Putrahttp://repository.unri.ac.id/xmlui/handle/123456789/5936Chalconesbelongto important classofflavonoid compounds.Theyhavealsobeen reported to have anticancer, antimicrobial, antifungal, antioxidant, and cytotoxic activities. In this research, an analogous chalcone of(E)-3-(4clorophenyl)-1-(3’,4’ dimetoxyphenyl) prop- 2-en-1-on wassynthesized using microwaveiradiation and natriumhidroxideas catalyst. Thecompound showed a goodyield,and then was characterizedbyUVspectroscopy,IR, 1 H-NMR,andMassSpectroscopy.Its toxicity hasbeenidentified usingBrineShrimpLethalityTest(BSLT) methodonArtemia salina Leach. The result showed that it had a good toxicity activity with LC50=2.24µg/mLandpotentialasanticancer.other3’,4’-dimetoxyacetophenoneBSLTchalconestoxicityOther