Abstract:
Chalcone is one of the secondary metabolites of the flavonoid group that has two aromatic
rings connected by three carbon α, β unsaturated, the distribution of chalcone compounds in
nature is very limited but has many important biological activities. In this research, symmetric
chalcone (2E, 2'E) -3.3'- (1,4-phenylene) bis (1- (3-methoxyphenyl) prop-2-en-1-on chalcone
was carried out and toxicity testing of these compounds. Chalcone compound was synthesized
from the aldol condensation reaction between 3-methoxyacetophenone and terepthaldialdeid
which was catalyzed by the NaOH base using stirring at 0-5 0C. The purity of the coumpounds
was determined using by KLT test, melting point and HPLC analysis. Compounds structure
was analyzed using UV spectroscopy, FTIR, 1H-NMR, and HRMS. The yield obtained from
the synthesis is 31,25 %. Compounds toxicity test K1-3OMe determined by the BSLT method
using shrimp larvae (Arthemia Salina Leach). LC50 value of compounds K1-3OMe is
216,27μg/mL. Concluded that the compound K1-3OMe are not toxic.
