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SINTESIS DAN UJI TOKSISITAS ANALOG DARI TURUNAN KALKON (E)-3-(4-HIDROKSIFENIL)-1- (2-METOKSIFENIL)-PROP-2-EN-1-ONE

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dc.contributor.author Dani, Rahma
dc.contributor.author Eryanti, Yum
dc.date.accessioned 2019-08-15T03:44:25Z
dc.date.available 2019-08-15T03:44:25Z
dc.date.issued 2019-08-15
dc.identifier.other wahyu sari yeni
dc.identifier.uri https://repository.unri.ac.id/handle/123456789/9815
dc.description.abstract Pyrazole is a important group of five ring heterocyclic alkaloid compounds containing two adjacent nitrogen atoms which have a diverse biological activities such as anti-inflammatory, analgesic, and antioxidant. Chalcone analogue of (E)-3-(4-hidroksifenil)-1-(2-metoksifenil)-prop-2en-1-one was synthesized via oxidative aromatization reaction with phenylhydrazine and catalyzed with glacial acetic acid. Chalcone was synthesized via microwave at 180 W and and pyrazoles were synthesized via reflux at 80oC. The purity of the compounds were determined by TLC, melting point and HPLC analysis. The structure of synthesized compounds were confirmed by UV, FTIR, NMR and HRMS spectroscopy studies. The toxicity of pyrazol was evaluated by Brine Shrimp Lethality Test (BSLT) method. Pyrazole PFC-4OH-2OMe considered toxicity as LC50= 165.95 μg/mL because the value of LC50 is less than 200 μg/mL en_US
dc.description.provenance Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2019-08-15T03:44:25Z No. of bitstreams: 1 Jurnal Ilmiah Rahma Baru.pdf: 2961365 bytes, checksum: 5af483c265e220b6ec43316aef27e249 (MD5) en
dc.description.provenance Made available in DSpace on 2019-08-15T03:44:25Z (GMT). No. of bitstreams: 1 Jurnal Ilmiah Rahma Baru.pdf: 2961365 bytes, checksum: 5af483c265e220b6ec43316aef27e249 (MD5) Previous issue date: 2019-08-15 en
dc.description.sponsorship JURUSAN KIMIA FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM UNIVERSITAS RIAU en_US
dc.language.iso en en_US
dc.publisher wahyu sari yeni en_US
dc.subject Alkaloid en_US
dc.subject Brine Shrimp Lethality Test en_US
dc.subject reflux en_US
dc.subject pyrazol en_US
dc.subject toxicity en_US
dc.title SINTESIS DAN UJI TOKSISITAS ANALOG DARI TURUNAN KALKON (E)-3-(4-HIDROKSIFENIL)-1- (2-METOKSIFENIL)-PROP-2-EN-1-ONE en_US
dc.type Article en_US


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